Rnls^tm1Gvd
Targeted Allele Detail

Summary

• Symbol: Rnls^tm1Gvd
• Name: renalase, FAD-dependent amine oxidase; targeted mutation 1, Gary V Desir
• MGI ID: MGI:5433853
• Gene: Rnls Location: Chr19:33115147-33369665 bp, - strand Genetic Position: Chr19, 29.08 cM
• Alliance: Rnls^tm1Gvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186878
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 1 through 4. Western blot analysis confirmed the absence of protein expression in the kidney and heart. (J:186878)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rnls Mutation: 21 strains or lines available

References

• Original: J:186878 Wu Y, et al., Renalase deficiency aggravates ischemic myocardial damage. Kidney Int. 2011 Apr;79(8):853-60
• All: 7 reference(s)