Tg(Col11a2-cre)4Nhzi
Transgene Detail

Summary

• Symbol: Tg(Col11a2-cre)4Nhzi
• Name: transgene insertion 4, Nobumichi Hozumi
• MGI ID: MGI:5435262
• Synonyms: alpha2(XI) collagen-Cre line #4
• Transgene: Tg(Col11a2-cre)4Nhzi Location: unknown
• Alliance: Tg(Col11a2-cre)4Nhzi page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Col11a2-cre)4Nhzi expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Col11a2

• Mutation details: Cre recombinase replaced the beta-galactosidase gene in a construct containing the -742bp Col11a2 promoter sequence, SV40 RNA splice site, lacZ sequence, and Col11a2 first intron. The 4.2 kb construct was microinjected into fertilized pronuclei. 5 founders were obtained. 2 lines (1 and 5) did show recombination in crosses to lacZ reporter mice. Line 2 showed cre activity in neural tissue and line 3 had ubiquitous activity. Line 4 was chosen due to its restricted cre activity pattern, although it had a low transgene copy number compared to the other lines. (J:187063)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Col11a2 (species not specified) Summary of all recombinase alleles driven by Col11a2. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:187063 Fujimaki R, et al., Expression of Cre recombinase in the mouse developing chondrocytes driven by the mouse alpha2(XI) collagen promoter. J Bone Miner Metab. 2005;23(3):270-3
• All: 1 reference(s)