Xdh^renf
Chemically induced Allele Detail

Summary

• Symbol: Xdh^renf
• Name: xanthine dehydrogenase; Renal Failure
• MGI ID: MGI:5435289
• Synonyms: RENF
• Gene: Xdh Location: Chr17:74190890-74257191 bp, - strand Genetic Position: Chr17, 45.25 cM
• Alliance: Xdh^renf page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was identified in an ENU screen. DNA sequencing revealed a nonsense mutation at codon 26 that co-segregated with affected RENF mice. (J:187066)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Xdh Mutation: 101 strains or lines available

References

• Original: J:187066 Piret SE, et al., A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation. PLoS One. 2012;7(9):e45217
• All: 1 reference(s)