Fktn^tm1Kcam
Targeted Allele Detail

Summary

• Symbol: Fktn^tm1Kcam
• Name: fukutin; targeted mutation 1, Kevin P Campbell
• MGI ID: MGI:5435571
• Gene: Fktn Location: Chr4:53713745-53765785 bp, + strand Genetic Position: Chr4, 28.74 cM
• Alliance: Fktn^tm1Kcam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187144
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT flanked neo selection cassette were inserted upstream of exon 2 while a second loxP site was inserted downstream. (J:187144)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fktn Mutation: 44 strains or lines available

References

• Original: J:187144 Beedle AM, et al., Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy. J Clin Invest. 2012 Sep 4;122(9):3330-42
• All: 4 reference(s)