Fktn^tm1.2Kcam
Targeted Allele Detail

Summary

• Symbol: Fktn^tm1.2Kcam
• Name: fukutin; targeted mutation 1.2,
• MGI ID: MGI:5435589
• Gene: Fktn Location: Chr4:53713745-53765785 bp, + strand Genetic Position: Chr4, 28.74 cM
• Alliance: Fktn^tm1.2Kcam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187144
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT flanked neo selection cassette were inserted upstream of exon 2 while a second loxP site was inserted downstream. Mice were subsequently crossed to an cre expressing strain to excise exon2. (J:187144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fktn Mutation: 44 strains or lines available

References

• Original: J:187144 Beedle AM, et al., Mouse fukutin deletion impairs dystroglycan processing and recapitulates muscular dystrophy. J Clin Invest. 2012 Sep 4;122(9):3330-42
• All: 4 reference(s)