Shank3^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Shank3^tm1.1Geno
• Name: SH3 and multiple ankyrin repeat domains 3; targeted mutation 1.1, Genoway
• MGI ID: MGI:5435700
• Synonyms: Shank3^alphabeta-, SHANK3delta11^-
• Gene: Shank3 Location: Chr15:89383826-89444464 bp, + strand Genetic Position: Chr15, 44.96 cM
• Alliance: Shank3^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186719
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 11 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 11 via homologous recombination. Recombinase mediated recombination deleted exon 11 and the neo cassette. (J:186719)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shank3 Mutation: 85 strains or lines available

References

• Original: J:186719 Schmeisser MJ, et al., Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature. 2012 Jun 14;486(7402):256-60
• All: 20 reference(s)