Slc8a1^tm1Herc
Targeted Allele Detail

Summary

• Symbol: Slc8a1^tm1Herc
• Name: solute carrier family 8 (sodium/calcium exchanger), member 1; targeted mutation 1, Andre Herchuelz
• MGI ID: MGI:5436242
• Gene: Slc8a1 Location: Chr17:81680534-82045806 bp, - strand Genetic Position: Chr17, 51.29 cM
• Alliance: Slc8a1^tm1Herc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186743
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 11 was replaced with a neo cassette. RT-PCR confirmed reduction in transcript expression in pancreatic islets. (J:186743)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc8a1 Mutation: 55 strains or lines available

References

• Original: J:186743 Nguidjoe E, et al., Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, beta-cell proliferation, and mass. Diabetes. 2011 Aug;60(8):2076-85
• All: 2 reference(s)