Adar^tm2Knk
Targeted Allele Detail

Summary

• Symbol: Adar^tm2Knk
• Name: adenosine deaminase, RNA-specific; targeted mutation 2, Kazuko Nishikura
• MGI ID: MGI:5436438
• Gene: Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Adar^tm2Knk page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:65981
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 12 and 13 which encode part of the catalytic domain were replaced by a PGK-neomycin cassette. (J:65981)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adar Mutation: 72 strains or lines available

References

• Original: J:65981 Wang Q, et al., Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis. Science. 2000 Dec 1;290(5497):1765-8
• All: 2 reference(s)