Spred1^tm1.1Ayos
Targeted Allele Detail

Summary

• Symbol: Spred1^tm1.1Ayos
• Name: sprouty protein with EVH-1 domain 1, related sequence; targeted mutation 1.1, Akihiko Yoshimura
• MGI ID: MGI:5436575
• Synonyms: Spred1^flox
• Gene: Spred1 Location: Chr2:116951855-117012760 bp, + strand Genetic Position: Chr2, 59.03 cM, cytoband E5
• Alliance: Spred1^tm1.1Ayos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186742
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo cassette flanked by loxP and FRT sites was inserted upstream of exon 7. An additional loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exon 7 floxed. (J:186742)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Spred1 Mutation: 38 strains or lines available

References

• Original: J:186742 Ishizaki T, et al., miR126 positively regulates mast cell proliferation and cytokine production through suppressing Spred1. Genes Cells. 2011 Jul;16(7):803-14
• All: 5 reference(s)