Acot13^tm1Deco
Targeted Allele Detail

Summary

• Symbol: Acot13^tm1Deco
• Name: acyl-CoA thioesterase 13; targeted mutation 1, David E Cohen
• MGI ID: MGI:5437122
• Synonyms: Them2^-
• Gene: Acot13 Location: Chr13:25001938-25015472 bp, - strand Genetic Position: Chr13, 10.69 cM, cytoband A3.2
• Alliance: Acot13^tm1Deco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183258
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exons 2 and 3. Western blot analusis confirmed the absence of protein expression in the liver, white adipose tissue and muscle. (J:183258)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Acot13^tm1Deco/Acot13^tm1Deco	involves: 129 * C57BL/6
hm2	Acot13^tm1Deco/Acot13^tm1Deco	Not Specified

Phenotypes:

Affected Systems	hm1	hm2
show or hide all annotated terms
adipose tissue	√	√
decreased white adipose tissue amount	√
decreased brown fat cell lipid droplet size		√
decreased epididymal fat pad weight	√
behavior/neurological	√	√
abnormal eating behavior	√
decreased food intake		√
increased food intake		√
decreased locomotor activity	√
hyperactivity		√
digestive/alimentary system	√
abnormal feces lipid level	√
growth/size/body	√	√
increased lean body mass	√	√
decreased body weight	√
increased body weight		√
homeostasis/metabolism	√	√
abnormal adaptive thermogenesis		√
decreased circulating ketone body level	√
increased core body temperature		√
abnormal circadian temperature homeostasis		√
increased energy expenditure		√
decreased oxygen consumption	√
increased oxygen consumption		√
decreased respiratory quotient	√
increased respiratory quotient		√
abnormal glucose homeostasis	√
abnormal gluconeogenesis	√
improved glucose tolerance	√
abnormal lipid level	√
abnormal feces lipid level	√
decreased circulating free fatty acids level	√
decreased liver cholesterol level	√
decreased liver triglyceride level	√
decreased basal metabolism	√
abnormal enzyme/coenzyme activity	√
liver/biliary system	√
decreased liver cholesterol level	√
decreased liver triglyceride level	√
decreased susceptibility to diet-induced hepatic steatosis	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acot13 Mutation: 11 strains or lines available

References

• Original: J:183258 Kang HW, et al., Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism. FASEB J. 2012 May;26(5):2209-21
• All: 7 reference(s)