Acot13^tm1Deco
Targeted Allele Detail

Summary

• Symbol: Acot13^tm1Deco
• Name: acyl-CoA thioesterase 13; targeted mutation 1, David E Cohen
• MGI ID: MGI:5437122
• Synonyms: Them2^-
• Gene: Acot13 Location: Chr13:25001938-25015472 bp, - strand Genetic Position: Chr13, 10.69 cM, cytoband A3.2
• Alliance: Acot13^tm1Deco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183258
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exons 2 and 3. Western blot analusis confirmed the absence of protein expression in the liver, white adipose tissue and muscle. (J:183258)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acot13 Mutation: 11 strains or lines available

References

• Original: J:183258 Kang HW, et al., Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism. FASEB J. 2012 May;26(5):2209-21
• All: 7 reference(s)