Sox7^tm1.1Dsco
Targeted Allele Detail

Summary

• Symbol: Sox7^tm1.1Dsco
• Name: SRY (sex determining region Y)-box 7; targeted mutation 1.1, Daryl A Scott
• MGI ID: MGI:5437221
• Synonyms: Sox7^-
• Gene: Sox7 Location: Chr14:64181155-64188181 bp, + strand Genetic Position: Chr14, 33.34 cM, cytoband C3
• Alliance: Sox7^tm1.1Dsco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187416
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Recombinase mediated recombination removed exon 2 and the neo cassette. (J:187416)

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox7 Mutation: 21 strains or lines available

References

• Original: J:187416 Wat MJ, et al., Mouse model reveals the role of SOX7 in the development of congenital diaphragmatic hernia associated with recurrent deletions of 8p23.1. Hum Mol Genet. 2012 Sep 15;21(18):4115-25
• All: 2 reference(s)