Dock8^tm1Ysfk
Targeted Allele Detail

Summary

• Symbol: Dock8^tm1Ysfk
• Name: dedicator of cytokinesis 8; targeted mutation 1, Yoshinori Fukui
• MGI ID: MGI:5437274
• Gene: Dock8 Location: Chr19:24976898-25179796 bp, + strand Genetic Position: Chr19, 19.91 cM
• Alliance: Dock8^tm1Ysfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185165
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 3 and 4. Western blot confirmed the absence of protein expression in spleen cell lysates. (J:185165)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock8 Mutation: 103 strains or lines available

References

• Original: J:185165 Harada Y, et al., DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood. 2012 May 10;119(19):4451-61
• All: 8 reference(s)