Antxr2^tm1.1Jkit
Targeted Allele Detail

Summary

• Symbol: Antxr2^tm1.1Jkit
• Name: anthrax toxin receptor 2; targeted mutation 1.1, Jan K Kitajewski
• MGI ID: MGI:5437300
• Synonyms: Antxr2^-
• Gene: Antxr2 Location: Chr5:98032547-98178876 bp, - strand Genetic Position: Chr5, 47.77 cM, cytoband E3
• Alliance: Antxr2^tm1.1Jkit page

Reproductive tract abnormalities in aged nulliparous Antxr2^tm1.1Jkit/Antxr2^tm1.1Jkit mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187210
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1 via homologous recombination. Cre mediated recombination removed exon 1 and the neo cassette. (J:187210)

Generation of the Antxr2^tm1Jkit and Antxr2^tm1.1Jkit alleles

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Antxr2 Mutation: 43 strains or lines available

References

• Original: J:187210 Reeves CV, et al., Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity. PLoS One. 2012;7(4):e34862
• All: 1 reference(s)