Ctbs^tm1Tbec
Targeted Allele Detail

Summary

• Symbol: Ctbs^tm1Tbec
• Name: chitobiase; targeted mutation 1, Tommaso Beccari
• MGI ID: MGI:5437306
• Gene: Ctbs Location: Chr3:146156204-146171604 bp, + strand Genetic Position: Chr3, 71.26 cM, cytoband H3
• Alliance: Ctbs^tm1Tbec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185162
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 2. Western blot analysis confirmed the absence of protein expression in the liver. (J:185162)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctbs Mutation: 19 strains or lines available

References

• Original: J:185162 Persichetti E, et al., Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2. Biochim Biophys Acta. 2012 Jul;1822(7):1137-46
• All: 1 reference(s)