Stat5a^tm1.1Wjl
Targeted Allele Detail

Summary

• Symbol: Stat5a^tm1.1Wjl
• Name: signal transducer and activator of transcription 5A; targeted mutation 1.1, Warren J Leonard
• MGI ID: MGI:5437316
• Gene: Stat5a Location: Chr11:100750177-100775995 bp, + strand Genetic Position: Chr11, 63.77 cM
• Alliance: Stat5a^tm1.1Wjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187325
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions in exons 3 and 4 results in the amino acid substitutions of alanine for isoleucine at position 28 and phenylalanine at position 81 (I28A and F81A). A floxed neo cassette was removed by cre-mediated recombination. (J:187325)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat5a Mutation: 48 strains or lines available

References

• Original: J:187325 Lin JX, et al., Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. Immunity. 2012 Apr 20;36(4):586-99
• All: 3 reference(s)