Gt(ROSA)26Sor^{tm1.1(Ctnna3,EGFP)Jvh}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(Ctnna3,EGFP)Jvh}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Jolanda van Hengel
• MGI ID: MGI:5437345
• Synonyms: Rosa26^alphaTctn
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(Ctnna3,EGFP)Jvh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187209
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(Ctnna3,EGFP)Jvh} expresses 2 genes
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ctnna3 (MGI:2661445)
  mouse	Ctnna3 (MGI:2661445)

• Mutation details: A targeted vector containing a floxed STOP/neo cassette, the mouse Ctnna3 cDNA, and an IRES-EGFP was inserted into the locus. Cre-mediated recombination removed the STOP/neo cassette and allowed for expression of the cDNA and EGFP. (J:187209)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:187209 Tyberghein K, et al., Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice. Placenta. 2012 Jul;33(7):554-60
• All: 1 reference(s)