Kcnn3^tm2.2Jpad
Targeted Allele Detail

Summary

• Symbol: Kcnn3^tm2.2Jpad
• Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; targeted mutation 2.2, John P Adelman
• MGI ID: MGI:5437368
• Gene: Kcnn3 Location: Chr3:89427471-89579801 bp, + strand Genetic Position: Chr3, 39.16 cM, cytoband F2
• Alliance: Kcnn3^tm2.2Jpad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187145
• Parent Cell Line: Duffy (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Kcnn3^tm2.1Jpad removed exon 1. Western blot analysis confirmed the absence of protein expression in the brain. (J:187145)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnn3 Mutation: 51 strains or lines available

References

• Original: J:187145 Deignan J, et al., SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons. Neuroscience. 2012 Aug 16;217:67-76
• All: 2 reference(s)