Elmod1^rda-2J
Spontaneous Allele Detail

Summary

• Symbol: Elmod1^rda-2J
• Name: ELMO/CED-12 domain containing 1; roundabout 2 Jackson
• MGI ID: MGI:5437446
• Gene: Elmod1 Location: Chr9:53818741-53882585 bp, - strand Genetic Position: Chr9, 29.35 cM
• Alliance: Elmod1^rda-2J page

Cochlear hair cell abnormalities in rda/rda and Elmod1^rda-2J/Elmod1^rda-2J mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: B10.BR-H2^k2 H2-T18^a/SgSnJ

Mutation description

Allele Type: Spontaneous (Null/knockout) Mutation: Duplication Elmod1^rda-2J involves 1 genes/genome features (Elmod1) View all Mutation details: A spontaneous mutation results in a 606 bp intragenic duplication of exons 3 through 8. Western blot analysis confirmed the absence of a 62 kDa protein compared with the wild-type 36 kDa. (J:187273)

Molecular structure of the Elmod1^rda-2J mutation

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Elmod1 Mutation: 35 strains or lines available

References

• Original: J:187273 Johnson KR, et al., Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia. PLoS One. 2012;7(4):e36074
• All: 1 reference(s)