Rhbdf2^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Rhbdf2^m1Btlr
• Name: rhomboid 5 homolog 2; mutation 1, Bruce Beutler
• MGI ID: MGI:5437475
• Synonyms: iRhom2^I387F, Rhbdf2^sin, Rhbdf2^sinecure
• Gene: Rhbdf2 Location: Chr11:116488991-116517786 bp, - strand Genetic Position: Chr11, Syntenic
• Alliance: Rhbdf2^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to T transversion that results in the amino acid substitution of phenylalanine for isoleucine at position 387 (I387F). This allele is hypomorphic. (J:187583)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rhbdf2 Mutation: 84 strains or lines available

References

• Original: J:187583 Siggs OM, et al., iRhom2 is required for the secretion of mouse TNFalpha. Blood. 2012 Jun 14;119(24):5769-71
• All: 2 reference(s)