Shank2^tm1Mgle
Targeted Allele Detail

Summary

• Symbol: Shank2^tm1Mgle
• Name: SH3 and multiple ankyrin repeat domains 2; targeted mutation 1, Min Goo Lee
• MGI ID: MGI:5437479
• Gene: Shank2 Location: Chr7:143555665-143978231 bp, + strand Genetic Position: Chr7, 88.45 cM
• Alliance: Shank2^tm1Mgle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186718
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An approximately 3.1 kb genomic fragment including exons 6 and 7 was replaced with a floxed neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in the brains of homozygous mice. (J:186718)

Disease models

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shank2 Mutation: 92 strains or lines available

References

• Original: J:186718 Won H, et al., Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature. 2012 Jun 14;486(7402):261-5
• All: 23 reference(s)