Ceacam16^tm1Wzm
Targeted Allele Detail

Summary

• Symbol: Ceacam16^tm1Wzm
• Name: CEA cell adhesion molecule 16; targeted mutation 1, Wolfgang Zimmermann
• MGI ID: MGI:5437595
• Gene: Ceacam16 Location: Chr7:19586022-19595224 bp, - strand Genetic Position: Chr7, 9.95 cM
• Alliance: Ceacam16^tm1Wzm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187537
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced exons 2 through 4 and part of exon 5. Western blot analysis confirmed the absence of protein expression. (J:187537)

Generation of the Ceacam16^tm1Wzm allele

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ceacam16 Mutation: 24 strains or lines available

References

• Original: J:187537 Kammerer R, et al., Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies. J Biol Chem. 2012 Jun 22;287(26):21584-98
• All: 1 reference(s)