Havcr1^tm1Kuch
Targeted Allele Detail

Summary

• Symbol: Havcr1^tm1Kuch
• Name: hepatitis A virus cellular receptor 1; targeted mutation 1, Vijay K Kuchroo
• MGI ID: MGI:5437711
• Synonyms: Kim-1^deltamucin, Tim-1^deltamucin
• Gene: Havcr1 Location: Chr11:46630644-46670405 bp, + strand Genetic Position: Chr11, 28.08 cM
• Alliance: Havcr1^tm1Kuch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186484
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a pgk-neo cassette via homologous recombination. Western blot analysis detected the expression of a shortened protein in heterozygous mice. These shortened proteins lacking the O-glycosylated mucin domain are expressed on the surface of B cells. (J:186484)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Havcr1 Mutation: 29 strains or lines available

References

• Original: J:186484 Xiao S, et al., Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12105-10
• All: 9 reference(s)