Pabpc1l^tm1.1Esel
Targeted Allele Detail

Summary

• Symbol: Pabpc1l^tm1.1Esel
• Name: poly(A) binding protein, cytoplasmic 1-like; targeted mutation 1.1, Emre Seli
• MGI ID: MGI:5437740
• Gene: Pabpc1l Location: Chr2:163867370-163892458 bp, + strand Genetic Position: Chr2, 84.6 cM
• Alliance: Pabpc1l^tm1.1Esel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187525
• Parent Cell Line: S1B6 (ES Cell)
• Strain of Origin: 129S1/SvImJ or C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exon 2. Cre-mediated recombination removed the neo cassette. RT-PCR confirmed the absence of protein expression in ovaries. (J:187525)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pabpc1l Mutation: 34 strains or lines available

References

• Original: J:187525 Guzeloglu-Kayisli O, et al., Embryonic poly(A)-binding protein (EPAB) is required for oocyte maturation and female fertility in mice. Biochem J. 2012 Aug 15;446(1):47-58
• All: 5 reference(s)