Eif2ak2^tm1Ajs
Targeted Allele Detail

Summary

• Symbol: Eif2ak2^tm1Ajs
• Name: eukaryotic translation initiation factor 2-alpha kinase 2; targeted mutation 1, Anthony J Sadler
• MGI ID: MGI:5438001
• Synonyms: eIF2k2^tm1Lri
• Gene: Eif2ak2 Location: Chr17:79159993-79190002 bp, - strand Genetic Position: Chr17, 49.56 cM, cytoband E2
• Alliance: Eif2ak2^tm1Ajs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187314
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nculeotide substitutions (AAG to CGG) result in the amino acid substitution of arginine for lysine at position 271 (K271R). Cre-mediated recombination removed the neo cassette and leaves a 121 lox in intron 9. This mutation is expected to ablate kinase activity. (J:187314, J:240799)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif2ak2 Mutation: 41 strains or lines available

References

• Original: J:187314 Irving AT, et al., Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. Immunity. 2012 May 25;36(5):795-806
• All: 4 reference(s)