Hprt1^{tm2(CAG-Myof)Isrd}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm2(CAG-Myof)Isrd}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Isabelle Richard
• MGI ID: MGI:5438010
• Synonyms: TgMyof
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm2(CAG-Myof)Isrd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187293
• Parent Cell Line: BPES (ES Cell)
• Strain of Origin: (129-Hprt1^b-m3 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm2(CAG-Myof)Isrd} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myof (MGI:1919192)

• Mutation details: A transgene containing the mouse cDNA under the control of the ubiquitous CAG promoter was inserted into the locus. (J:187293)

Schematic representation of the Hprt1^{tm2(CAG-Myof)Isrd} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:187293 Lostal W, et al., Lack of correlation between outcomes of membrane repair assay and correction of dystrophic changes in experimental therapeutic strategy in dysferlinopathy. PLoS One. 2012;7(5):e38036
• All: 1 reference(s)