Slc39a4^tm2Gka
Targeted Allele Detail

Summary

• Symbol: Slc39a4^tm2Gka
• Name: solute carrier family 39 (zinc transporter), member 4; targeted mutation 2, Glen K Andrews
• MGI ID: MGI:5438020
• Synonyms: Zip4^FX
• Gene: Slc39a4 Location: Chr15:76496583-76501579 bp, - strand Genetic Position: Chr15, 36.16 cM
• Alliance: Slc39a4^tm2Gka page

Growth retardation of tamoxifen treated Slc39a4^tm2Gka/Slc39a4^tm2Gka Tg(Vil1-cre/ERT2)23Syr/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187178
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site and flanking XhoI restriction site were introduced in intron 5 and a loxP site and mc1-neo cassette were introduced downstream of the last exon via homologous recombination. (J:187178)

Generation of the Slc39a4^tm2Gka allele

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc39a4 Mutation: 29 strains or lines available

References

• Original: J:187178 Geiser J, et al., A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. PLoS Genet. 2012 Jun;8(6):e1002766
• All: 3 reference(s)