Brca2^tm1.1Sks
Targeted Allele Detail

Summary

• Symbol: Brca2^tm1.1Sks
• Name: breast cancer 2, early onset; targeted mutation 1.1, Shyam K Sharan
• MGI ID: MGI:5438023
• Synonyms: Brca2^F2351D
• Gene: Brca2 Location: Chr5:150446095-150493794 bp, + strand Genetic Position: Chr5, 89.52 cM
• Alliance: Brca2^tm1.1Sks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187434
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions (TTC to GAC) result in the amino acid substitution of aspartic acid for phenylalanine at position 2351 (F2351D). A floxed neo cassette inserted in intron 14 was removed by cre-mediated recombination. (J:187434)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brca2 Mutation: 132 strains or lines available

References

• Original: J:187434 Biswas K, et al., Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay. Hum Mol Genet. 2012 Sep 15;21(18):3993-4006
• All: 1 reference(s)