b2b1297Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b1297Clo
• Name: Mutant line 1297; Bench to Bassinet Program (B2B/CVDC), mutation 1297 Cecilia Lo
• MGI ID: MGI:5438057
• Synonyms: GCG
• Gene: b2b1297Clo Location: unknown
• Alliance: b2b1297Clo page

Mutant 1297-002-2 (E 14.5) displays malpositioning of the great arteries shown by EFIC imaging to be DORV

Show the 9 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b1297Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiovascular phenotype: Double outlet right ventricle (DORV), pulmonary stenosis, thickened semilunar and atrioventircular valves, atrioventricular septal defects (AVSD), ventricular septal defect (VSD)
Noncardiac phenotype: Hepatic cyst

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0600	Double outlet right ventricle
1300	Ventricular septal defect
1486	Thickened aortic valve cusp(s)
1610	Pulmonary stenosis
2050	Atrial septal defect
4447	Hepatic malformation

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)