b2b1700Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b1700Clo
• Name: Mutant line 1700; Bench to Bassinet Program (B2B/CVDC), mutation 1700 Cecilia Lo
• MGI ID: MGI:5438063
• Synonyms: Armadillo
• Gene: b2b1700Clo Location: unknown
• Alliance: b2b1700Clo page

Mutant 1700-007-LA displays situs inversus totalis indicated by mirror-image placement of the organs

Show the 7 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. Additional incidental mutations were detected in sequencing for the causative mutation, b2b1700Clo, and may be present in stocks carrying this mutation.

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b1700Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiac phenotype: Heterotaxy, double outlet right ventricle (DORV), transposition of the great arteries (TGA), atrioventricular septal defect (AVSD), vascular ring
Non-Cardiac phenotype: Short gut, immotile cilia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0110	Dextrocardia
0190	Heterotaxy syndrome
0600	Double outlet right ventricle
0700	D-loop transposition of the great arteries
2050	Atrial septal defect
2760	Vascular ring
4851	Kartagener syndrome (siewart syndrome)(primary ciliary dyskinesia)

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)