Il34^{tm1b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Il34^{tm1b(EUCOMM)Wtsi}
• Name: interleukin 34; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5438224
• Synonyms: Il34^LacZ
• Gene: Il34 Location: Chr8:111468461-111532556 bp, - strand Genetic Position: Chr8, 57.68 cM
• Alliance: Il34^{tm1b(EUCOMM)Wtsi} page
• IMPC: Il34 gene page

Mutation origin

• Mutant Cell Line: EPD0146_4_D03
• Germline Transmission: Earliest citation of germline transmission: J:187643
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated recombination of Il34^{tm1a(EUCOMM)Wtsi} removed exons 3 through 5. The FRT-flanked lacZ/neo cassette upstream of exon 3 remains intact. Immunohistochemistry confirmed the absence of protein expression in the brain and skin. (J:187643)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il34 Mutation: 23 strains or lines available

References

• Original: J:187643 Wang Y, et al., IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol. 2012;13(8):753-60
• All: 11 reference(s)