Cul4b^tm1Swl
Targeted Allele Detail

Summary

• Symbol: Cul4b^tm1Swl
• Name: cullin 4B; targeted mutation 1, Shu-Wha Lin
• MGI ID: MGI:5438236
• Synonyms: Cul4b^lox
• Gene: Cul4b Location: ChrX:37622151-37665073 bp, - strand Genetic Position: ChrX, 22.81 cM, cytoband A2
• Alliance: Cul4b^tm1Swl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187403
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. (J:187403)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cul4b Mutation: 37 strains or lines available

References

• Original: J:187403 Chen CY, et al., Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardation. Hum Mol Genet. 2012 Oct 1;21(19):4270-85
• All: 3 reference(s)