Ago4^tm1.1Peco
Targeted Allele Detail

Summary

• Symbol: Ago4^tm1.1Peco
• Name: argonaute RISC catalytic subunit 4; targeted mutation 1.1, Paula E Cohen
• MGI ID: MGI:5438526
• Gene: Ago4 Location: Chr4:126383334-126427265 bp, - strand Genetic Position: Chr4, 60.9 cM
• Alliance: Ago4^tm1.1Peco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187588
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted in intron 2 and an FRT flanked pgk-neo cassette and loxP site were inserted into intron 17 via homologous recombination. Recombinase mediated recombination removed exons 3-17 and the neo cassette. (J:187588)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ago4 Mutation: 43 strains or lines available

References

• Original: J:187588 Modzelewski AJ, et al., AGO4 Regulates Entry into Meiosis and Influences Silencing of Sex Chromosomes in the Male Mouse Germline. Dev Cell. 2012 Aug 14;23(2):251-64
• All: 1 reference(s)