Mrtfb^tm1.1Msp
Targeted Allele Detail

Summary

• Symbol: Mrtfb^tm1.1Msp
• Name: myocardin related transcription factor B; targeted mutation 1.1, Michael S Parmacek
• MGI ID: MGI:5438551
• Synonyms: Mkl2^-
• Gene: Mrtfb Location: Chr16:13074345-13235393 bp, + strand Genetic Position: Chr16, 9.24 cM
• Alliance: Mrtfb^tm1.1Msp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187713
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 8 and a neo cassette and loxP site were inserted downstream of exon 8 via homologous recombination. Cre mediated recombination deleted the neo cassette and exon 8. (J:187713)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrtfb Mutation: 68 strains or lines available

References

• Original: J:187713 Li J, et al., Myocardin-like protein 2 regulates TGFbeta signaling in embryonic stem cells and the developing vasculature. Development. 2012 Oct;139(19):3531-42
• All: 1 reference(s)