Tmeff2^tm1Fawa
Targeted Allele Detail

Summary

• Symbol: Tmeff2^tm1Fawa
• Name: transmembrane protein with EGF-like and two follistatin-like domains 2; targeted mutation 1, Fan Wang
• MGI ID: MGI:5438565
• Synonyms: Tmeff2^PLAP
• Gene: Tmeff2 Location: Chr1:50951946-51226429 bp, + strand Genetic Position: Chr1, 25.95 cM, cytoband C1
• Alliance: Tmeff2^tm1Fawa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187163
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct including a cDNA encoding human ALPP and a floxed neo cassette was inserted after the initiation codon replacing the rest of exon 1. In situ hybridization confirmed the absence of mRNA expression in homozygous embryos. (J:187163)

Expression

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tmeff2 Mutation: 35 strains or lines available

References

• Original: J:187163 Chen TR, et al., Generation and characterization of Tmeff2 mutant mice. Biochem Biophys Res Commun. 2012 Aug 24;425(2):189-94
• All: 2 reference(s)