Gt(ROSA)26Sor^{tm6(tetO-dTomato,-Ctnnb1*)Bgh}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm6(tetO-dTomato,-Ctnnb1*)Bgh}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Bernhard G Herrmann
• MGI ID: MGI:5438577
• Synonyms: Ctnnb1^mut, tet:tg-dTomato_TA_Ctnnb1^mut
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm6(tetO-dTomato,-Ctnnb1*)Bgh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187862
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence, RMCE-ready, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm6(tetO-dTomato,-Ctnnb1*)Bgh} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ctnnb1 (MGI:88276)

• Mutation details: Recombinase-mediated cassette exchange (RMCE) introduced into the locus a construct containing a tetracycline-responsive element that drives inducible expression of a tdTomato and mutated mouse cDNA (S33A, S37A, T41A, S45A) separated by a self-cleaving TA peptide. (J:187862)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:187862 Farrall AL, et al., Wnt and BMP signals control intestinal adenoma cell fates. Int J Cancer. 2012 Nov 15;131(10):2242-52
• All: 1 reference(s)