Nos3^tm1.2Taka
Targeted Allele Detail

Summary

• Symbol: Nos3^tm1.2Taka
• Name: nitric oxide synthase 3, endothelial cell; targeted mutation 1.2, Takamune Takahashi
• MGI ID: MGI:5438595
• Synonyms: Nos3^del(F1)
• Gene: Nos3 Location: Chr5:24569808-24589472 bp, + strand Genetic Position: Chr5, 11.32 cM
• Alliance: Nos3^tm1.2Taka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187860
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Nos3^tm1.1Taka removes exons 9 through 12. Western blot analysis confirmed the absence of wild-type protein in the kidney and lung with the detection of a truncated protein. (J:187860)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nos3 Mutation: 58 strains or lines available

References

• Original: J:187860 Jiang R, et al., Generation of a conditional allele for the mouse endothelial nitric oxide synthase gene. Genesis. 2012 Sep;50(9):685-92
• All: 2 reference(s)