Cebpa^tm2Btp
Targeted Allele Detail

Summary

• Symbol: Cebpa^tm2Btp
• Name: CCAAT/enhancer binding protein alpha; targeted mutation 2, Bo Torben Porse
• MGI ID: MGI:5438639
• Synonyms: Cebpa^S248A
• Gene: Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
• Alliance: Cebpa^tm2Btp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187834
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: Nucleotide substitution results in the amino acid substitution of serine with alanine at position 247 (p.S247A). This mutation changes the residue in the encoded peptide from phosphorylatable to a phosphoblocker. (J:187834)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpa Mutation: 19 strains or lines available

References

• Original: J:187834 Hasemann MS, et al., Phosphorylation of serine 248 of C/EBPalpha is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency. PLoS One. 2012;7(6):e38841
• All: 1 reference(s)