Tg(INS-icre)18Msdr
Transgene Detail

Summary

• Symbol: Tg(INS-icre)18Msdr
• Name: transgene insertion 19, Marlon R Schneider
• MGI ID: MGI:5438640
• Synonyms: PIP-iCre
• Transgene: Tg(INS-icre)18Msdr Location: unknown
• Alliance: Tg(INS-icre)18Msdr page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(INS-icre)18Msdr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  pig, domestic	INS

• Mutation details: A 1055 bp fragment encoding codon-improved cre recombinase was inserted into a vector containing a 1500 bp fragment of the 5' UTR of the porcine insulin promoter (PIP) of the insulin gene (INS). The purified construct was injected into C57BL/6 fertilized oocytes. 43 founders were obtained and two transmitted the transgene to their progeny. These founders were crossed to ROSA26lacZ reporter mice. Founder line 20 did not show any beta-galactosidase activity and was not analyzed further; line 18 displayed staining in essentially all islets, but not in the exocrine compartment and was more fully characterized. (J:179832)

Generation of Tg(INS-icre)18Msdr.

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	INS (pig, domestic) Summary of all recombinase alleles driven by INS.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:179832 Dahlhoff M, et al., A transgenic mouse line expressing cre recombinase in pancreatic beta-cells. Genesis. 2012 May;50(5):437-42
• All: 2 reference(s)