Fgf10^{tm1.1(cre/ERT2)Sbel}
Targeted Allele Detail

Summary

• Symbol: Fgf10^{tm1.1(cre/ERT2)Sbel}
• Name: fibroblast growth factor 10; targeted mutation 1.1, Saverio Bellusci
• MGI ID: MGI:5438701
• Synonyms: Fgf10Cre-ERT2, Fgf10^iCre, Fgf10Ki-v1
• Gene: Fgf10 Location: Chr13:118851199-118928651 bp, + strand Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
• Alliance: Fgf10^{tm1.1(cre/ERT2)Sbel} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187831
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Fgf10^{tm1.1(cre/ERT2)Sbel} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fgf10 (MGI:1099809)

• Mutation details: A targeting construct containing a cassette with the cre/ERT2 sequence followed by an IRES-YFP-polyA-neo fragment was injected into TVB2 ES cells. Homologous recombination intoduced the construct in frame with the ATG start codon of the Fgf10 exon 1. Chimeric animals were crossed to Flp-expressing mice to delete the neo selection cassette. It is a loss-of-function allele for Fgf10. (J:187831)

Generation of the Fgf10^{tm1.1(cre/ERT2)Sbel} allele.

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fgf10 (mouse) Summary of all recombinase alleles driven by Fgf10. Alliance mouse Fgf10 gene page

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf10 Mutation: 33 strains or lines available

Notes

allele made by GenOway

References

• Original: J:187831 El Agha E, et al., Characterization of a novel fibroblast growth factor 10 (Fgf10) knock-in mouse line to target mesenchymal progenitors during embryonic development. PLoS One. 2012;7(6):e38452
• All: 9 reference(s)