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Kdm6atm1a(EUCOMM)Jhha
Targeted Allele Detail
Summary
Symbol: Kdm6atm1a(EUCOMM)Jhha
Name: lysine (K)-specific demethylase 6A; targeted mutation 1a, Jacob H Hanna
MGI ID: MGI:5438704
Synonyms: Utxflox
Gene: Kdm6a  Location: ChrX:18028814-18146175 bp, + strand  Genetic Position: ChrX, 13.45 cM
Alliance: Kdm6atm1a(EUCOMM)Jhha page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186686
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph, Reporter)
Mutation:    Insertion
 
Mutation detailsThe targeting vector from EUCOMM was used to insert an FRT flanked lacZ and neo cassette and a loxP site upstream of exon 3 and a second loxP site downstream of exon 3 via homologous recombination. Slightly reduced levels of mRNA expression are seen in hemizygous male embryonic stem cells carrying this allele indicating that this is a hypomorphic allele. (J:186686)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm6a Mutation:  40 strains or lines available
Notes
In J:186686, the targeting construct was injected into V6.5 ES cells [(C57BL/6 x 129S4/SvJae)F1], V19-OSKM ES cells [(C57BL/6 x 129S4/SvJae)F1], and BVSC ES cells [(C57BL/6 x DBA)F2].
References
Original:  J:186686 Mansour AA, et al., The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature. 2012 Aug 16;488(7411):409-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory