Tyk2^tm1Biat
Targeted Allele Detail

Summary

• Symbol: Tyk2^tm1Biat
• Name: tyrosine kinase 2; targeted mutation 1, Biomodels Austria
• MGI ID: MGI:5438711
• Gene: Tyk2 Location: Chr9:21015364-21042539 bp, - strand Genetic Position: Chr9, 7.71 cM, cytoband A3
• Alliance: Tyk2^tm1Biat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65408
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced most of the exons encoding the Jak homology (JH) domains JH7 (partly), JH6/5 and JH4 (partly). Western blot analysis confirmed the absence of protein expression in bone marrow macrophage. (J:65408)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyk2 Mutation: 72 strains or lines available

References

• Original: J:65408 Karaghiosoff M, et al., Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity. 2000 Oct;13(4):549-60
• All: 24 reference(s)