Il17a/Il17f^tm1.1Impr
Targeted Allele Detail

Summary

• Symbol: Il17a/Il17f^tm1.1Impr
• Name: interleukin 17A; targeted mutation 1.1, Immo Prinz
• MGI ID: MGI:5438791
• Synonyms: Il17af^-
• Gene: Il17a Location: Chr1:20801129-20804720 bp, + strand Genetic Position: Chr1, 6.45 cM, cytoband A
• Alliance: Il17a/Il17f^tm1.1Impr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187400
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A self-excising floxed neo cassette replaced exon 2 and 3 of Il17a and Il17f. This allele lacks the neo cassette. Cell sorting confirmed the absence of T cells expressing either gene. (J:187400)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il17a Mutation: 25 strains or lines available

References

• Original: J:187400 Haas JD, et al., Development of interleukin-17-producing gammadelta T cells is restricted to a functional embryonic wave. Immunity. 2012 Jul 27;37(1):48-59
• All: 13 reference(s)