Dhx58^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Dhx58^tm1Itl
• Name: DExH-box helicase 58; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:5439127
• Gene: Dhx58 Location: Chr11:100585710-100595097 bp, - strand Genetic Position: Chr11, 63.52 cM
• Alliance: Dhx58^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187386
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaces exons 2 through 8. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:187386)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dhx58 Mutation: 37 strains or lines available

References

• Original: J:187386 Suthar MS, et al., The RIG-I-like Receptor LGP2 Controls CD8(+) T Cell Survival and Fitness. Immunity. 2012 Aug 24;37(2):235-48
• All: 5 reference(s)