Gpr37l1^tm1.2Gtva
Targeted Allele Detail

Summary

• Symbol: Gpr37l1^tm1.2Gtva
• Name: G protein-coupled receptor 37-like 1; targeted mutation 1.2, Glauco Tocchini-Valentini
• MGI ID: MGI:5439169
• Gene: Gpr37l1 Location: Chr1:135087988-135095419 bp, - strand Genetic Position: Chr1, 58.25 cM
• Alliance: Gpr37l1^tm1.2Gtva page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201190
• Parent Cell Line: XSV1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site was inserted upstream of exon 1 and a floxed neomycin resistance cassette was inserted in intron 1. Cre-mediated recombination removed the neo cassette and exon 1. Northern blot analysis confirmed the absence of transcript expression. Western blot analysis confirmed the absence of protein expression in the cerebellum. (J:201190)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr37l1 Mutation: 33 strains or lines available

References

• Original: J:201190 Marazziti D, et al., Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16486-16491
• All: 6 reference(s)