Nlgn3^tm1Rhn
Targeted Allele Detail

Summary

• Symbol: Nlgn3^tm1Rhn
• Name: neuroligin 3; targeted mutation 1, Rene Hen
• MGI ID: MGI:5439278
• Synonyms: Neuroligin 3 STOP-tetO, Nlgn3^KO, Nlgn3^STOP-tetO
• Gene: Nlgn3 Location: ChrX:100342785-100364956 bp, + strand Genetic Position: ChrX, 43.95 cM
• Alliance: Nlgn3^tm1Rhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159353
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Flexible Accelerated STOP Tetracycline Operator (tetO)-knockin (FAST) was used to insert a construct containing a loxP site, FRT site, neo cassette, STOP, FRT site, tetracycline operator (tetO) and loxP site was inserted upstream of the translation initiation site. (J:159353)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlgn3 Mutation: 36 strains or lines available

References

• Original: J:159353 Tanaka KF, et al., Flexible Accelerated STOP Tetracycline Operator-knockin (FAST): a versatile and efficient new gene modulating system. Biol Psychiatry. 2010 Apr 15;67(8):770-3
• All: 11 reference(s)