Znrf3^tm1Cle
Targeted Allele Detail

Summary

• Symbol: Znrf3^tm1Cle
• Name: zinc and ring finger 3; targeted mutation 1, Hans Clevers
• MGI ID: MGI:5439366
• Gene: Znrf3 Location: Chr11:5226329-5394847 bp, - strand Genetic Position: Chr11, 3.46 cM
• Alliance: Znrf3^tm1Cle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186765
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted between the exons encoding the RING domain and a loxP site was inserted downstream of these exons via homologous recombination. (J:186765)

Expression

In Mice Carrying this Mutation:

4 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Znrf3 Mutation: 37 strains or lines available

References

• Original: J:186765 Koo BK, et al., Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature. 2012 Aug 30;488(7413):665-9
• All: 8 reference(s)