Evc2^tm1.1Vlrp
Targeted Allele Detail

Summary

• Symbol: Evc2^tm1.1Vlrp
• Name: EvC ciliary complex subunit 2; targeted mutation 1.1, Victor L Ruiz-Perez
• MGI ID: MGI:5439465
• Gene: Evc2 Location: Chr5:37495843-37582399 bp, + strand Genetic Position: Chr5, 20.15 cM
• Alliance: Evc2^tm1.1Vlrp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188176
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An EGFP replaced exon 1. A loxP site was inserted in intron 1. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:188176)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Evc2 Mutation: 47 strains or lines available

References

• Original: J:188176 Caparros-Martin JA, et al., The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia. Hum Mol Genet. 2013 Jan 1;22(1):124-39
• All: 2 reference(s)