Ccm2^tm1Mlkn
Targeted Allele Detail

Summary

• Symbol: Ccm2^tm1Mlkn
• Name: cerebral cavernous malformation 2; targeted mutation 1, Mark L Kahn
• MGI ID: MGI:5439490
• Gene: Ccm2 Location: Chr11:6496887-6546744 bp, + strand Genetic Position: Chr11, 4.45 cM
• Alliance: Ccm2^tm1Mlkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187714
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. (J:187714)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccm2 Mutation: 48 strains or lines available

References

• Original: J:187714 Zheng X, et al., Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Dev Cell. 2012 Aug 14;23(2):342-55
• All: 9 reference(s)