Heg1^tm2.1Mlkn
Targeted Allele Detail

Summary

• Symbol: Heg1^tm2.1Mlkn
• Name: heart development protein with EGF-like domains 1; targeted mutation 2.1, Mark L Kahn
• MGI ID: MGI:5439491
• Gene: Heg1 Location: Chr16:33504754-33591946 bp, + strand Genetic Position: Chr16, 24.17 cM
• Alliance: Heg1^tm2.1Mlkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187714
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the 5' untranslated region and an FRT flanked neo cassette and loxP site were inserted downstream of exon 1 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:187714)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Heg1 Mutation: 56 strains or lines available

References

• Original: J:187714 Zheng X, et al., Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Dev Cell. 2012 Aug 14;23(2):342-55
• All: 1 reference(s)