Kpna1^tm1.2Yyo
Targeted Allele Detail

Summary

• Symbol: Kpna1^tm1.2Yyo
• Name: karyopherin subunit alpha 1; targeted mutation 1.2, Yoshihiro Yoneda
• MGI ID: MGI:5439493
• Synonyms: Impalpha5^-
• Gene: Kpna1 Location: Chr16:35803693-35859479 bp, + strand Genetic Position: Chr16, 25.43 cM, cytoband B4-B5
• Alliance: Kpna1^tm1.2Yyo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188099
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Flp-mediated recombination of Kpna1^tm1Yyo removed exons 2 and 3. Western blot analysis confirmed the absence of protein expression in the brain, thymus, lung, heart, kidney, liver, spleen, testis and ovary. (J:188099)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kpna1 Mutation: 68 strains or lines available

References

• Original: J:188099 Moriyama T, et al., Targeted disruption of one of the importin alpha family members leads to female functional incompetence in delivery. FEBS J. 2011 May;278(9):1561-72
• All: 3 reference(s)